Acne is the annoyance of many teens and adults. Now, scientists state that they may have hit on a novel approach to alleviate the condition. The key lies in physically produced skin oil known as sebum. The study was led by William Esler, a scientist with drug titan Pfizer in Cambridge, Massachusetts. Seemingly, sebum is significant to the skin’s health since it aids in regulating the temperature and fend off microbes, the team stated. But an overload of sebum production for long has been considered to be a contributor to acne. Dr. Raman Madan—Dermatologist at Northwell Health’s Huntington Hospital—said, “Too much sebum can get stuck in glands, which leads it to swell and root a bump under the skin.” So, it stands to cause that recognizing “a goal to lower sebum production will be a new approach to cure acne,” stated Madan, who was not involved in the study.
The research comprised a microscopic analysis of the skin of 22 fit volunteers. Esler’s research team found that skin sebum production depends on a particular molecular mechanism called the DNL (de novo lipogenesis) pathway. Most sebum was discovered to be produced by cells known as sebocytes, which produced the oil based on the ebb and gush of the DNL pathway, the scientists explained. But 9 people with acne demonstrated one main difference in comparison to people having normal skin, they had almost 20% greater rate of sebum generation and a linked elevation in instabilities of the DNL pathway, the observations showed.
On a similar note, recently, a study showed that mouse model validated how “good and bad” bacteria impact acne. For long, investigators have believed that Propionibacterium acnes causes acne. Apparently, these bacteria are ample on everyone’s skin and yet not everybody gets acne or encounters it to the same degree. Recently, the genetic sequencing disclosed that not all Propionibacterium acnes are the same as there are various strains, some of which are plentiful in acne abrasions and some that are never detected there.