An Atlas of the Human Brain’s Development Has Been Created by Scientists

An Atlas of the Human Brain's Development Has Been Created by Scientists

Aparna Bhaduri, a member of the study team of Indian ancestry, has created a diagram depicting the growth of the human brain. Anatomically complicated organs are represented by diagrams that depict the interconnected networks and genetic expressions that go into their construction. Researchers around the world could use this information to better understand the underlying causes of conditions including intellectual impairment, autism, and schizophrenia.

Scientists previously looked at how different types of DNA activity appeared in brain tissue taken from different individuals. In the field of human brain development, this approach facilitated the study of a novel class of neural stem cells. A study of stem cells and neurons in the developing brain has also revealed how these cells and neurons can support both normal brain development and neurodevelopmental disorder. When they’re done, they think this will be a useful resource for other researchers to use as a guide to gene expression in the developing brain. At the University of California at San Francisco, neuroscientists are working to construct an unbiased interpretation of the genes found in each type of brain cell during development so that patient-relevant mutations can be studied more closely for their effect on cells.

In addition, UCSF’s Alex Pollen stated that while finding gene variants that have similar risk aspects for mental and neurological disorders is authoritative, understanding precisely which sorts of brain cells are accepted is still perplexing. The atlas can be used as a bridge to assist and implement this with greater flexibility, he said. Additionally, the study looked at gene expression in specific cells across time and in different parts of the brain. To their surprise, the scientists were able to identify previously undetected changes in gene expression between neural stem cells that activate deep brain structures and neocortical surface cells.

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